Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

Myeloid-derived suppressor cells (MDSCs) play crucial roles in tumorigenesis and their inhibition is critical for successful cancer immunotherapy. MDSCs undergo metabolic reprogramming from glycolysis to fatty acid oxidation (FAO) and oxidative phosphorylation led by lipid accumulation in tumor. Inc...

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Principais autores:	Dehong Yan, Adeleye O. Adeshakin, Meichen Xu, Lukman O. Afolabi, Guizhong Zhang, Youhai H. Chen, Xiaochun Wan
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2019-06-01
סדרה:	Frontiers in Immunology
נושאים:	MDSCs lipid metabolism FAO-OXPHOS immunosuppressive cancer immunotherapy
גישה מקוונת:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01399/full
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