SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism

Abstract Background Cigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing redox imbalance. We previously showed that clearing mitochondrial reactive oxygen species (mtROS) protects against CS-induced pulmonary fibros...

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Detalhes bibliográficos

Principais autores:	Yue Zhang, Ting Li, Miaoxia Pan, Wei Wang, Wenhui Huang, Yafei Yuan, Zhanzhan Xie, Yixin Chen, Jun Peng, Xu Li, Ying Meng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-05-01
coleção:	Journal of Translational Medicine
Assuntos:	Cigarette smoking SIRT1 Mitochondrial oxidative stress Autophagy Lipid metabolism
Acesso em linha:	https://doi.org/10.1186/s12967-022-03408-5
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