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Variation in microbiome and metabolites is associated with advantageous effects of cholestyramine on primary biliary cholangitis with pruritus

ABSTRACT Emerging evidence implicates bile acid-intestinal microbiota interactions in the pathogenesis of pruritus associated with primary biliary cholangitis (PBC). Cholestyramine, a bile acid sequestrant, is clinically recommended for pruritus alleviation. This study investigates its regulatory ef...

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Principais autores: Yijun Zhou, Gaoxiang Ying, Wei Shen, Yusheng Cui, Bo Xiang, Muyuan Jiang, Jianfeng Bao, Qiaofei Jin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2026-02-01
coleção:Microbiology Spectrum
Assuntos:
primary biliary cholangitis
pruritus
microbiome
metabolites
cholestyramine
Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.00747-25
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