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The network pharmacology prediction and experiment validation of Astragalus membranaceus for alleviating silicosis fibrosis via decreasing MMP9 and EGFR expression

Abstract To investigate the molecular mechanism of Astragalus membranaceus (AM) in alleviating silicosis fibrosis using bioinformatics and in vitro experiments. Active ingredients of AM and their corresponding targets were retrieved from the TCMSP and SwissTargetPrediction databases. These ingredien...

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Principais autores: Anning Yang, Xiaoyu Luo, Yi Guo, Huning Zhang, Wenyue Zhang, Sirong Chang, Shengpeng Wen, Wenyan Yang, Yue Sun
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2026-03-01
סדרה:Scientific Reports
נושאים:
Astragalus membranaceus
Silicosis
Quercetin
Network pharmacology
Molecular docking
גישה מקוונת:https://doi.org/10.1038/s41598-026-42544-6
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