Adaptive Laboratory Evolution of Flavin Functionality Identifies Dihydrolipoyl Dehydrogenase as One of the Critical Points for the Activity of 7,8-Didemethyl-Riboflavin as a Surrogate for Riboflavin in <i>Escherichia coli</i>

Riboflavin analogs lacking one methyl group (7α or 8α) can still serve as a surrogate for riboflavin in riboflavin-deficient microorganisms or animals. The absence of both methyl groups at once completely abolishes this substitution capability. To elucidate the molecular mechanisms behind this pheno...

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Autors principals:	Farshad La-Rostami, Alexandra Scharf, Chenyang Albert, Nils Wax, Marina Creydt, Boris Illarionov, Adelbert Bacher, Stefan Weber, Markus Fischer
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-12-01
Col·lecció:	Molecules
Matèries:	riboflavin analogs isoalloxazine flavoproteins adaptive laboratory evolution whole genome sequencing
Accés en línia:	https://www.mdpi.com/1420-3049/29/24/5891
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