Lack of shared neoantigens in prevalent mutations in cancer

Abstract Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA damage checkpoint, DNA repair machinery and mitotic checkpoint. Defect in one or more of these mechanisms causes additive accumulation of mutations. Some of these mutations...

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Principais autores:	Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte, Luigi Buonaguro
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2024-04-01
Serija:	Journal of Translational Medicine
Teme:	Mutations Neoantigens Tumor-associated antigens Tumor-specific antigens Cancer vaccines Molecular mimicry
Online dostop:	https://doi.org/10.1186/s12967-024-05110-0
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