Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx

Introductions: Excessive mechanical stress is closely associated with cell death in various conditions. Exposure of chondrocytes to excessive mechanical loading leads to a catabolic response as well as exaggerated cell death. Ferroptosis is a recently identified form of cell death during cell aging...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Shaoyi Wang, Weiwei Li, Pengfei Zhang, Zihao Wang, Xiaoyuan Ma, Chuanju Liu, Krasimir Vasilev, Lei Zhang, Xiaocong Zhou, Liang Liu, John Hayball, Shuli Dong, Yuhua Li, Yuan Gao, Lei Cheng, Yunpeng Zhao
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2022-11-01
Rangatū:	Journal of Advanced Research
Ngā marau:	Chondrocytes Osteoarthritis Ferroptosis Mechanical stress Piezo1
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2090123222000042
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!