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Single-cell analysis reveals the regulatory role of ECT2 in HPV-driven cervical carcinogenesis process

Abstract Background This study attempted to investigate possible mechanisms of human papillomavirus (HPV) infection from high-grade squamous intraepithelial lesions (HSIL) to cervical cancer (CESC) by combining bulk RNA-seq and scRNA-seq data of CESC. Methods scRNA-seq (GSE208653) and bulk RNA-seq (...

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Main Authors: Shuyi Huang, Xiaoning Wei, Yong Wang, Yudi Tan, Shasha Yang, Jinkong Wei, Yuying Wei, Yuxuan Jin, Linqing Li, Junying Chen
Format: Artigo
Language:Inglês
Published: BMC 2025-09-01
Series:Infectious Agents and Cancer
Subjects:
HPV
High-grade squamous intraepithelial lesion
CESC
ECT2
Epithelial cells
scRNA-seq
Online Access:https://doi.org/10.1186/s13027-025-00696-6
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