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An estrogen receptor/E2F1/CDKN3 axis protects from UV-induced skin cancers in females

Abstract Men have a higher risk of developing cutaneous squamous cell carcinoma (SCC) compared with women, but models and comprehensive analyses of signaling pathways highlighting this sexual dimorphism are missing. Here, we use a UV-induced SCC model in hairless mice recapitulating this sex differe...

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Principais autores: Céline Lukowicz, Carine Winkler, Catherine Roger, Joanna C Fowler, Yi-Chien Tsai, Joachim Meuli, Stéphanie Claudinot, Yun-Tsan Chang, Christoph Iselin, Philip H Jones, Emmanuella Guenova, Paris Jafari, Liliane Michalik
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2026-03-01
Serier:EMBO Reports
Fag:
UV-induced Squamous Cell Carcinoma
Skin
Proliferation
Estrogen Receptors
E2F Transcription Factors
Online adgang:https://doi.org/10.1038/s44319-026-00743-2
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