Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

The accumulation of DNA and RNA oxidative damage is observed in cortical and hippocampal neurons from Alzheimer's disease (AD) brains at early stages of pathology. We recently reported that Tau is a key nuclear player in the protection of neuronal nucleic acid integrity in vivo under physiological c...

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Egile Nagusiak:	Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Galas
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2015-10-01
Saila:	Neurobiology of Disease
Gaiak:	Tau Tau oligomers Alzheimer Hyperthermia Oxidative stress DNA damage
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S0969996115300498
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