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Long-Term Persistence of Mitochondrial DNA Instability in HIV-Exposed Uninfected Children during and after Exposure to Antiretroviral Drugs and HIV

HIV-exposed uninfected (HEU) children show impaired health outcomes during childhood. A high rate of mitochondrial DNA (mtDNA) instability was reported in the blood of HEU at birth. We aimed to explore the relationship between these health outcomes and mtDNA deletions over time in a case series of 2...

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Principais autores: Valérie Desquiret-Dumas, Morgana D’Ottavi, Audrey Monnin, David Goudenège, Nicolas Méda, Amélie Vizeneux, Chipepo Kankasa, Thorkild Tylleskar, Céline Bris, Vincent Procaccio, Nicolas Nagot, Philippe Van de Perre, Pascal Reynier, Jean-Pierre Molès
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-07-01
Serier:Biomedicines
Fag:
HIV
neonates
mitochondria
clinical outcomes
neurodevelopment
genetic alterations
Online adgang:https://www.mdpi.com/2227-9059/10/8/1786
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