Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection

ABSTRACT In this study, we investigated the impact of G protein-coupled receptor (GPCR) signaling on the intracellular replication of the model pathogen Brucella neotomae. Building on a prior chemical genetics screen, we identified agonists of the Gαi-coupled adenosine A1 and dopamine D4 receptors a...

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Detalles Bibliográficos

Autores principales:	Yoon-Suk Kang, James E. Kirby
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology 2026-06-01
Colección:	mBio
Materias:	Brucella intracellular pathogens G proteins phosphodiesterase inhibitors G protein-coupled receptors (GPCRs) macrophage host signaling
Acceso en línea:	https://journals.asm.org/doi/10.1128/mbio.00040-26
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