Effects of sevoflurane and its metabolite hexafluoroisopropanol on hypoxia/reoxygenation-induced injury and mitochondrial bioenergetics in murine cardiomyocytes

Background: The volatile anaesthetic sevoflurane protects cardiac tissue from reoxygenation/reperfusion. Mitochondria play an essential role in conditioning. We aimed to investigate how sevoflurane and its primary metabolite hexafluoroisopropanol (HFIP) affect necrosis, apoptosis, and reactive oxyge...

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Detalhes bibliográficos

Principais autores:	Birgit Roth Z'graggen, Martin Urner, Beatrice Beck-Schimmer, Martin Schläpfer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-03-01
coleção:	BJA Open
Assuntos:	hexafluoroisopropanol hypoxia/reoxygenation injury mitochondrial bioenergy measurements mitochondrial membrane potential depolarisation oxygen consumption rate postconditioning
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2772609622001150
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