Rapid vinyl thianthrenium tetrafluoroborate-promoted thioacid-based native chemical ligation and its applications in chemical protein synthesis

Abstract Native chemical ligation (NCL) has emerged as the most extensively employed chemoselective reaction in chemical protein synthesis (CPS). Nevertheless, the inherently low reactivity of peptide alkyl thioesters often necessitates the use of excessive nucleophilic additives in NCL to facilitat...

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Κύριοι συγγραφείς:	Hanghang Li, Shujuan Xu, Zhichao Zhang, Rujie Xie, Jingying Liu, Junjie Ma, Congshen Zheng, Changmai Chen, Wei Chen, Jiaan Liu
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2026-01-01
Σειρά:	Communications Chemistry
Διαθέσιμο Online:	https://doi.org/10.1038/s42004-025-01811-9
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