Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control

In atopic dermatitis (AD), lesional skin is frequently colonized by Staphylococcus aureus, which promotes clinical symptoms of the disease. The inflammatory milieu in the skin is characterized by a Th2 response, including M2 macrophages, which cannot eradicate S. aureus. Therefore, repolarization of...

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Bibliografische Detailangaben

Hauptverfasser:	Christina Schmidt, Kunjan Harit, Stephan Traidl, Michael Naumann, Thomas Werfel, Lennart M. Roesner, Gopala Nishanth, Dirk Schlüter
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-01-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	Staphylococcus aureus macrophage CYLD ubiquitin atopic dermatitis STAT1
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1507989/full
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