Effects of MEK-inhibitor treatment in infants with lymphatic abnormalities in noonan syndrome

Noonan syndrome (NS) is a genetic disorder associated with dysregulation of the RAS/MAPK signaling pathway and is frequently accompanied by lymphatic abnormalities. These lymphatic complications can lead to severe clinical manifestations, including chylous effusions and respiratory compromise, parti...

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主要な著者:	J. Wagenpfeil, K. Hoß, A. Henkel, D. L. Kütting, J. A. Luetkens, A. Mueller, C. C. Pieper, A. Groteklaes
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-07-01
シリーズ:	Frontiers in Pediatrics
主題:	central conducting lymphatic anomaly lymphedema MEK-inhibition therapy MR lymphangiography noonan syndrome trametinib
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fped.2026.1842723/full
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