Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

Abstract Paternal lifestyle and environmental exposures can alter epigenetic changes in sperm and play a critical role in the offspring's future health, yet the underlying mechanisms remain elusive. The present study established a model of paternal obesity and found that the increased levels of H3K2...

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Hauptverfasser:	Yajun Shi, Weisheng Li, Xi Yu, Yan Zhao, Dan Zhu, Yueyang Song, Zejun Zhao, Yannan Gu, Bin Wei, Lingjun Li, Dongyi Yu, Pengjie Zhang, Qinqin Gao, Miao Sun
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2025-04-01
Schriftenreihe:	Advanced Science
Schlagworte:	H3K27me3 MANF paternal obesity sperm transgenerational inheritance
Online-Zugang:	https://doi.org/10.1002/advs.202415956
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