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kLa based scale-up cultivation of the extremophilic archaeon Sulfolobus acidocaldarius: from benchtop to pilot scale

The two major scale-up criteria in continuously stirred bioreactors are 1) constant aerated power input per volume (Pg/Vl), and 2) the volumetric O2 mass transfer coefficient (kla). However, Pg/Vl is only influenced by the stirrer geometry, stirrer speed, aeration and working volume, while the kla i...

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Bibliografiset tiedot
Päätekijät: Kerstin Rastädter, David J. Wurm, Oliver Spadiut, Julian Quehenberger
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2023-08-01
Sarja:Frontiers in Bioengineering and Biotechnology
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Linkit:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1160012/full
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