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Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial

Abstract Background Ventilator-induced diaphragmatic dysfunction (VIDD) occurs in up to 60% of mechanically ventilated patients and prolongs ventilatory dependance. The consequences of VIDD are muscle atrophy, reduction of strength, and injury of muscle fibers. Atrophy and contractile activity of th...

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Gorde:
Egile Nagusiak: Annia F. Schreiber, Carles Subirà, Michael Sklar, Marlene Santos, Matthew Ko, Alessandro Panelli, Stefan J. Schaller, Danny Theodore, Daniel D. Rowley, David Watson, Pramod Bonde, Elias N. Baedorf Kassis, Daniel S. Talmor, Marco Ranieri, Ewan C. Goligher, Arthur Slutsky, Laurent J. Brochard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMC 2025-06-01
Saila:Trials
Gaiak:
Ventilator-induced diaphragm dysfunction
Phrenic nerve stimulation
Ultrasonography
Mechanical ventilation
Critical illness
Critical care
Sarrera elektronikoa:https://doi.org/10.1186/s13063-025-08838-2
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