Targeting microglia-mediated neuroinflammation via pH-responsive lipid nanoparticle delivery of HDAC inhibitor RGFP966 in ischemic stroke

Ischemic stroke (IS) remains a leading cause of global disability and mortality, with limited effective anti-inflammatory interventions. Targeting histone deacetylase 3 (HDAC3) to reprogram microglial polarization holds great therapeutic promise, but the HDAC3-specific inhibitor RGFP966 suffers from...

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Váldodahkkit:	Yaqi Liu, Biao Luo, Yun Xu, Dexiang Liu, Qiujing Wang
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Taylor & Francis Group 2026-07-01
Ráidu:	Science and Technology of Advanced Materials
Fáttát:	Ischemic stroke ph-responsive LNP microglia neuroinflammation HDAC
Liŋkkat:	https://www.tandfonline.com/doi/10.1080/14686996.2026.2699624
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