Modeling of clinical phenotypes in systemic lupus erythematosus based on the platelet transcriptome and FCGR2a genotype

Abstract Background The clinical heterogeneity of SLE with its complex pathogenesis remains challenging as we strive to provide optimal management. The contribution of platelets to endovascular homeostasis, inflammation and immune regulation highlights their potential importance in SLE. Prior work f...

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Hlavní autoři:	MacIntosh G. Cornwell, Hanane El Bannoudi, Elliot Luttrell-Williams, Alexis Engel, Tessa J. Barrett, Khrystyna Myndzar, Peter Izmirly, H. Michael Belmont, Robert Clancy, Kelly V. Ruggles, Jill P. Buyon, Jeffrey S. Berger
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-04-01
Edice:	Journal of Translational Medicine
Témata:	Platelet Lupus RNA-seq Transcriptomics FCGR2a Lupus Nephritis
On-line přístup:	https://doi.org/10.1186/s12967-023-04059-w
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