Biomarkers for hypertrophic chondrocyte differentiation are associated with spatial cellular organisation and suggest endochondral ossification-like processes in osteoarthritic cartilage: An exploratory study

Background: In healthy articular cartilage, chondrocytes are found along arcades of collagen fibers as Single Strings. With onset of cartilage degeneration this pattern changes to Double Strings. In the course of osteoarthritis Small Clusters, and finally Big Clusters form. In highly degenerated art...

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Detalhes bibliográficos

Principais autores:	Julius Michael Wolfgart, Lea Cathrine Grötzner, Sascha Hemayatkar-Fink, Maik Schwitalle, Florian Christof Bonnaire, Martina Feierabend, Marina Danalache, Ulf Krister Hofmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-09-01
Colecção:	Journal of Orthopaedic Translation
Assuntos:	Angiogenesis Articular cartilage Endochondral ossification Hypertrophic differentiation Osteoarthritis Spatial chondrocyte organization
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2214031X24000937
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