Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells

Discrimination between hematopoietic stem cells and leukemic stem cells remains a major challenge for acute myeloid leukemia immunotherapy. CAR T cells specific for the CD117 antigen can deplete malignant and healthy hematopoietic stem cells before consolidation with allogeneic hematopoietic stem ce...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Chiara F. Magnani, Renier Myburgh, Silvan Brunn, Morgane Chambovey, Marianna Ponzo, Laura Volta, Francesco Manfredi, Christian Pellegrino, Steve Pascolo, Csaba Miskey, Zoltán Ivics, Judith A. Shizuru, Dario Neri, Markus G. Manz
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2023-09-01
Serier:	Molecular Therapy: Oncolytics
Fag:	Chimeric antigen receptor CAR non-viral gene transfer acute myeloid leukemia cancer immunotherapy hematopoietic stem cell
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2372770523000499
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!