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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension culture model of high-grade serous ovarian cancer (HGSO...

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Autors principals: Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications Ltd 2024-07-01
Col·lecció:eLife
Matèries:
Netrin
high grade serous ovarian cancer
Dyrk1a
dormancy
quiescence
spheroids
Accés en línia:https://elifesciences.org/articles/91766
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