Intrinsic muscle stem cell dysfunction underlies functional deficits in models of type 1 diabetes

Abstract Muscle function and regeneration are impaired in type 1 diabetes, but whether this arises directly from muscle stem cell (MuSC) dysfunction has not been addressed. Here, we utilized three-dimensional MuSC cultures (micromuscles) to demonstrate that hyperglycemia drives deficits in muscle st...

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Hlavní autoři:	Jin D. Chung, Jennifer Trieu, Benjamin L. Parker, John H. Nguyen, Annabel Chee, Audrey S. Chan, Abhirup Jayasimhan, Devy Deliyanti, Peter J. Houweling, Holly K. Voges, Karly C. Sourris, Richard J. Mills, Melinda T. Coughlan, Jennifer L. Wilkinson-Berka, Enzo R. Porrello, Gordon S. Lynch
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-01-01
Edice:	npj Regenerative Medicine
On-line přístup:	https://doi.org/10.1038/s41536-025-00452-9
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