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Expression of antibody-drug conjugate targets in post-mortem samples of breast cancer metastases and normal tissue

Abstract While many Antibody Drug Conjugates (ADCs) are investigated in solid tumors, their target expression and heterogeneity is poorly documented in metastatic breast cancer. Here, we perform RNA sequencing to investigate expression of 72 ADC targets in 909 samples from 30 female patients from ou...

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Asıl Yazarlar: Kristien Borremans, Anirudh Pabba, Gitte Zels, Amena Mahdami, Camille Carette, Marion Maetens, Karen Van Baelen, Josephine Van Cauwenberge, Ha Linh Nguyen, Hava Izci, Sophia Leduc, Sigrid Hatse, Madita Nysen, Bram Boeckx, Evy Vanderheyden, Thomas Van Brussel, Françoise Derouane, Kevin Punie, Wouter Van Den Bogaert, Peter Vermeulen, Elia Biganzoli, Diether Lambrechts, Patrick Neven, Hans Wildiers, Giuseppe Floris, François Richard, Christine Desmedt
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2025-12-01
Seri Bilgileri:Nature Communications
Online Erişim:https://doi.org/10.1038/s41467-025-67840-z
Etiketler: Etiketle
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