The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene

Background: Mutations in the glucocerebrosidase (GBA1) and leucine-rich repeat kinase 2 (LRRK2) genes, encoding lysosomal enzyme glucocerebrosidase (GCase) and leucine-rich repeat kinase 2 (LRRK2), respectively, are the most common related to Parkinson’s disease (PD). Recent data suggest a possible...

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Hlavní autoři:	Tatiana S. Usenko, Alla Timofeeva, Mariia Beletskaia, Katerina Basharova, Galina Baydakova, Anastasia Bezrukova, Maria Grunina, Anton Emelyanov, Irina Miliukhina, Ekaterina Zakharova, Sofya Pchelina
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	IMR Press 2024-01-01
Edice:	Journal of Integrative Neuroscience
Témata:	parkinson's disease gba1 lrrk2 lysosomal enzyme activity lysosphingolipids
On-line přístup:	https://www.imrpress.com/journal/JIN/23/1/10.31083/j.jin2301016
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