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Novel syngeneic model of anti-mouse CLDN18.2 CAR -T therapy for gastric cancer demonstrates a synergy with TGF-β and PD-L1 inhibitors

There are very few syngeneic mouse cell line models available for gastric cancer owing to the rarity of stomach epithelium-specific promoter. Mouse cell line models are useful to study an immunologically intact tumor microenvironment, especially in the setting of CAR-T studies that often use immunoc...

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Principais autores: Min-Jung Seo, Jin Hue Jeong, Han Na Park, In-Pyo Baek, Jun Won Park, Seo Young Kim, Yu Ri Choi, Seulki Choi, Seung Min Ham, Dongmin Park, Hye-Ran Kim, Ho Kyung Seo, Hark Kyun Kim
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-03-01
Serier:Molecular Therapy: Oncology
Fag:
MT: Regular Issue
mouse
claudin
transforming growth factor
CAR-T
gastric cancer
Online adgang:http://www.sciencedirect.com/science/article/pii/S2950329925001894
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