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Adenoviruses Encapsulated in PEGylated DOTAP-Folate Liposomes Are Protected from the Pre-Existing Humoral Immune Response

<b>Background/Objectives</b>: While adenovirus (Ad) therapies have been proven to be effective in local administration, systemic Ad treatments have shown limited success due to pre-existing antibodies in the human blood that neutralize the virus. We developed a liposome coating procedure that protec...

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Principais autores: Abraham T. Phung, Jaimin R. Shah, Tao Dong, Omonigho Aisagbonhi, William C. Trogler, Andrew C. Kummel, Sarah L. Blair
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-06-01
coleção:Pharmaceutics
Assuntos:
liposome
adenovirus
PEG
neutralizing antibodies
systemic administration
Acesso em linha:https://www.mdpi.com/1999-4923/17/6/769
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