ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice

Abstract Background Alzheimer’s disease (AD) is defined by amyloid beta (Aβ) plaques and neurofibrillary tangles and characterized by neurodegeneration and memory loss. The majority of AD patients also have Aβ deposition in cerebral vessels known as cerebral amyloid angiopathy (CAA), microhemorrhage...

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Bibliografiske detaljer

Principais autores:	Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens, Cheryl L. Wellington
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2019-05-01
Serier:	Alzheimer’s Research & Therapy
Fag:	Alzheimer’s disease High-density lipoproteins Apolipoprotein A-I (apoA-I) Amyloid beta Cerebral amyloid angiopathy Neuroinflammation
Online adgang:	http://link.springer.com/article/10.1186/s13195-019-0497-9
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