Protein kinase CK2α is overexpressed in classical hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may represent a new target for therapy

IntroductionIn classical Hodgkin lymphoma (cHL), the survival of neoplastic cells is mediated by the activation of NF-κB, JAK/STAT and PI3K/Akt signaling pathways. CK2 is a highly conserved serine/threonine kinase, consisting of two catalytic (α) and two regulatory (β) subunits, which is involved in...

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Główni autorzy:	Edoardo Ruggeri, Federica Frezzato, Nayla Mouawad, Marco Pizzi, Federico Scarmozzino, Guido Capasso, Valentina Trimarco, Laura Quotti Tubi, Alessandro Cellini, Chiara Adele Cavarretta, Valeria Ruocco, Andrea Serafin, Francesco Angotzi, Nicolò Danesin, Sabrina Manni, Monica Facco, Francesco Piazza, Livio Trentin, Andrea Visentin
Format:	Artigo
Język:	Inglês
Wydane:	Frontiers Media S.A. 2024-05-01
Seria:	Frontiers in Immunology
Hasła przedmiotowe:	classical hodgkin lymphoma anti-CD30 MMAE CK2 PD-L1
Dostęp online:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1393485/full
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