Structure–activity relationship studies of 5-(Pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 inhibitors

Indoleamine 2,3-dioxygenase 1 (IDO1) is the key enzyme that catalyzes the conversion of l-tryptophan (Trp) to N-formyl-kynurenine in the tryptophan-kynurenine (Trp-Kyn) pathway. Overexpression of IDO1 contributes to the depletion of Trp and the accumulation of Kyn, which can result in tumor immune e...

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Hauptverfasser:	Jiawei Zhang, Jingyi Liu, Kaimin Kong, Xingzhou Li, Qian Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-01-01
Schriftenreihe:	Results in Chemistry
Schlagworte:	Indoleamine 2,3-dioxygenase 1 Cancer immunotherapy Marine alkaloid 1H-Indole-4,7-diones Molecular dynamic simulations
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211715623005246
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