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Intracellular Delivery of a p21-Derived Cell Cycle Inhibitory Peptide Using Elastin-like Polypeptides Suppresses Glioblastoma Cell Proliferation

Glioblastoma, with a 5-year survival rate of just under 7.0%, is the most common form of brain cancer in adults. In this study, we evaluated the antiproliferative activity of the biopolymer p21-ELP1-Bac, a p21-derived peptide delivered via an elastin-like polypeptide (ELP1) carrier and a cell-penetr...

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Principais autores: Tiffany Quinn, Yumnaa Shaheen, Drazen Raucher
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-02-01
Serier:Molecules
Fag:
p21
glioblastoma
elastin-like polypeptide
lineage specific
drug tolerance
antiproliferative
Online adgang:https://www.mdpi.com/1420-3049/31/4/597
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