NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels

Abstract Background Fully functional regeneration of skeletal defects by multipotent progenitor cells requires that differentiating cells gain the specific mechano-competence needed in the target tissue. Using cartilage neogenesis as an example, we asked whether proper phenotypic differentiation of...

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Detalhes bibliográficos

Principais autores:	Janine Lückgen, Elisabeth Raqué, Tobias Reiner, Solvig Diederichs, Wiltrud Richter
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-04-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Mesenchymal stromal cells (MSC) Chondrocytes Mechanical loading NFκB Extracellular matrix (ECM) synthesis Tissue engineering
Acesso em linha:	https://doi.org/10.1186/s13287-022-02843-x
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