Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening

Abstract Bifunctional targeted protein degraders, also known as Proteolysis Targeting Chimeras (PROTACs), are an emerging drug modality that may offer a new approach for treating neurodegenerative diseases. Identifying chemical starting points for PROTACs remains a largely empirical process and the...

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Principais autores:	Andreas Holmqvist, Nur Mehpare Kocaturk, Christina Duncan, Jennifer Riley, Steven Baginski, Graham Marsh, Joel Cresser-Brown, Hannah Maple, Kristiina Juvonen, Gajanan Sathe, Nicola Morrice, Calum Sutherland, Kevin D. Read, William Farnaby
格式:	Artigo
語言:	Inglês
出版:	Nature Portfolio 2025-10-01
叢編:	Nature Communications
在線閱讀:	https://doi.org/10.1038/s41467-025-63928-8
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