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Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model

IntroductionThe mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclophosphamide and other cytotoxic drugs are currently understood through two main explanatory theories: apoptosis and over-activation. Discrepancies between the findings of differen...

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Wedi'i Gadw mewn:
Prif Awduron: Xia Hao, Arturo Reyes Palomares, Amandine Anastácio, Kui Liu, Kenny A. Rodriguez-Wallberg
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2024-10-01
Cyfres:Frontiers in Endocrinology
Pynciau:
ovary
primordial follicle
growing follicle
cyclophosphamide
apoptosis
overactivation
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fendo.2024.1322592/full
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