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Association between gut microbiota and Hirschsprung disease: a bidirectional two-sample Mendelian randomization study

BackgroundSeveral studies have pointed to the critical role of gut microbiota (GM) and their metabolites in Hirschsprung disease (HSCR) pathogenesis. However, the detailed causal relationship between GM and HSCR remains unknown.MethodsIn this study, we used two-sample Mendelian randomization (MR) an...

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Principais autores: Wei Liu, Hanlei Yan, Wanying Jia, Jingjing Huang, Zihao Fu, Wenyao Xu, Hui Yu, Weili Yang, Weikang Pan, Baijun Zheng, Yong Liu, Xinlin Chen, Ya Gao, Donghao Tian
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Microbiology
Assuntos:
Mendelian randomization analysis
Hirschsprung disease
gut microbiota
causality
bidirectional
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1366181/full
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