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LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

Effective therapy for liver fibrosis is lacking. Here, we examined whether LP340, the lead candidate of a new-generation of hydrazide-based HDAC1,2,3 inhibitors (HDACi), decreases liver fibrosis. Liver fibrosis was induced by CCl4 treatment and bile duct ligation (BDL) in mice. At 6 weeks after CCl4...

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Principais autores: Devadoss J. Samuvel, John J. Lemasters, C. James Chou, Zhi Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-05-01
coleção:Frontiers in Pharmacology
Assuntos:
histone deacetylase
liver fibrosis
microRNA-23a
oxidative stress
SnoN
TGFβ
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2024.1386238/full
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