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Immunological Aspects of X-Linked Chronic Granulomatous Disease Female Carriers

X-linked Granulomatous Disease (XL-CGD) carriers were previously thought to be clinically healthy because random X-chromosome inactivation (XCI) allows approximately half of their phagocytes/monocytes to express functional gp91phox protein. This supports the NADPH oxidase activity necessary for the...

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Autori principali: Maria Chiriaco, Irene Salfa, Giorgiana Madalina Ursu, Cristina Cifaldi, Silvia Di Cesare, Paolo Rossi, Gigliola Di Matteo, Andrea Finocchi
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-06-01
Serie:Antioxidants
Soggetti:
chronic granulomatous disease (CGD)
X-linked CGD carrier
reactive oxygen species (ROSs)
nicotinamide dinucleotide phosphate oxidase (NADPH)
dihydrorhodamine (DHR) assay
X-chromosome inactivation (XCI)
Accesso online:https://www.mdpi.com/2076-3921/10/6/891
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