Influence of AAV vector tropism on long-term expression and Fc-γ receptor binding of an antibody targeting SARS-CoV-2

Abstract Long-acting passive immunization strategies are needed to protect immunosuppressed vulnerable groups from infectious diseases. To further explore this concept for COVID-19, we constructed Adeno-associated viral (AAV) vectors encoding the human variable regions of the SARS-CoV-2 neutralizing...

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Detalles Bibliográficos

Principais autores:	Jannik T. Wagner, Sandra M. Müller-Schmucker, Wenjun Wang, Philipp Arnold, Nadja Uhlig, Leila Issmail, Valentina Eberlein, Dominik Damm, Kaveh Roshanbinfar, Armin Ensser, Friederike Oltmanns, Antonia Sophia Peter, Vladimir Temchura, Silke Schrödel, Felix B. Engel, Christian Thirion, Thomas Grunwald, Manfred Wuhrer, Dirk Grimm, Klaus Überla
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2024-07-01
Series:	Communications Biology
Acceso en liña:	https://doi.org/10.1038/s42003-024-06529-3
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