NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene.

We demonstrate that during inflammatory responses the nuclear factor kappa B (NF-κB) induces the synthesis of melatonin by macrophages and that macrophage-synthesized melatonin modulates the function of these professional phagocytes in an autocrine manner. Expression of a DsRed2 fluorescent reporter...

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Detalhes bibliográficos

Principais autores:	Sandra Marcia Muxel, Marco Antonio Pires-Lapa, Alex Willian Arantes Monteiro, Erika Cecon, Eduardo Koji Tamura, Lucile Maria Floeter-Winter, Regina P Markus
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2012-01-01
coleção:	PLoS ONE
Acesso em linha:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284853/?tool=EBI
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