Fully Automated Serum LC-MS/MS Platform and Pediatric Reference Intervals for Organic Acids, Amino Acids, and Acylcarnitines in Children (Ages 0–6 Years): Toward Quantitative Diagnosis of Inborn Errors of Metabolism

<b>Background/Objectives:</b> Conventional diagnosis of inborn errors of metabolism (IEMs) requires multiple specimen types—urine organic acids, plasma amino acids, and serum acylcarnitines—analyzed on distinct analytical platforms. This multi-assay approach is labor-intensive and limits timely clin...

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Detalhes bibliográficos

Principais autores:	Yasushi Ueyanagi, Daiki Setoyama, Tsuyoshi Nakanishi, Yuichi Mushimoto, Vlad Tocan, Hironori Kobayashi, Miki Matsui, Shinya Matsumoto, Akiyoshi Fujishima, Taeko Hotta, Ayumi Sakata, Yuya Kunisaki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-03-01
coleção:	Diagnostics
Assuntos:	liquid chromatography–tandem mass spectrometry (LC–MS/MS) inborn errors of metabolism (IEMs) organic acids amino acids acylcarnitines pediatric reference intervals
Acesso em linha:	https://www.mdpi.com/2075-4418/16/6/911
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