Evaluation of histone deacetylase inhibitory and antiproliferative activity of piperine and its derivatives
Piperine (1) was obtained from the seeds of Piper nigrum L. It could act as a pan-histone deacetylase (HDAC) inhibitor. This lead compound was structurally modified to six derivatives that exhibited improved HDAC inhibitory activity. Based on the preliminary results, amide derivatives (1e and 1f)...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Prince of Songkla University
2022-12-01
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| coleção: | Songklanakarin Journal of Science and Technology (SJST) |
| Assuntos: | |
| Acesso em linha: | https://sjst.psu.ac.th/journal/44-6/12.pdf |
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