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Impact of adaptive filtering on power and false discovery rate in RNA-seq experiments

Abstract Background In RNA-sequencing studies a large number of hypothesis tests are performed to compare the differential expression of genes between several conditions. Filtering has been proposed to remove candidate genes with a low expression level which may not be relevant and have little or no...

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Wedi'i Gadw mewn:
Prif Awduron: Sonja Zehetmayer, Martin Posch, Alexandra Graf
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2022-09-01
Cyfres:BMC Bioinformatics
Pynciau:
Next generation sequencing
Gene expression
Multiple testing
Gene filter
Mynediad Ar-lein:https://doi.org/10.1186/s12859-022-04928-z
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