FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster

Abstract STING is an evolutionarily conserved key regulator of innate immunity. In the model organism Drosophila melanogaster, STING activates the NF-κB-like transcription factor Relish, initially characterized for its role in the antibacterial IMD pathway. The versatile FADD/Caspase-8 axis is widel...

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Hlavní autoři:	Kasper Grønbjerg Winther, Juliette Schneider, Gabrielle Haas, Anna Hvarregaard Christensen, Shreya Goyal, Weisheng Luo, Ziming Wei, Jiyong Liu, Katarzyna Kjøge, Jan J Enghild, Carine Meignin, Neal Silverman, Hua Cai, Jean-Luc Imler, Rune Hartmann
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2026-03-01
Edice:	The EMBO Journal
Témata:	Innate Immunity FADD STING Death Fold Domain Drosophila Melanogaster
On-line přístup:	https://doi.org/10.1038/s44318-026-00761-9
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