Chromosome 1 variants associated with decreased HIV set-point viral load correlate with PRKAB2 expression changes

A previous study investigated a genomic region on chromosome 1 associated with reduced human immunodeficiency virus type 1 (HIV) set-point viral load, implicating CHD1L as a novel HIV inhibitory factor. However, given that regulatory variants can influence expression of multiple nearby genes, furthe...

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Autori principali:	Riley H. Tough, Paul J. McLaren
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-03-01
Serie:	Frontiers in Genetics
Soggetti:	genome-wide association studies bioinformatics PRKAB2 RNA-sequencing HIV - human immunodeficiency virus
Accesso online:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1551171/full
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