A luciferase-based hRBC-NSG mouse model to evaluate anti-CelTOS transmission-blocking antibodies against P. falciparum

Abstract Background Reliable experimental platforms are essential for evaluating transmission-blocking interventions against Plasmodium falciparum (P. falciparum). Although the standard membrane feeding assay (SMFA) is widely used to assess transmission-blocking activity, it is performed in vitro an...

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Detalhes bibliográficos

Principais autores:	Shulin Xu, Alison E. Roth, Richard Thomson-Luque, Nichole Salinas, Samantha Barnes, Courtney Herman, Niraj H. Tolia, John H. Adams
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	Malaria Journal
Assuntos:	Plasmodium falciparum Transmission-blocking antibodies CelTOS Luciferase assay Humanized mouse model
Acesso em linha:	https://doi.org/10.1186/s12936-026-05894-0
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