Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses

Abstract The risk of developing Parkinson’s disease (PD) is elevated in individuals with type 2 diabetes (T2DM), but the molecular pathways underlying this link remain unclear. Glycation, a non-enzymatic modification of lysine and arginine residues by reducing sugars or reactive dicarbonyls, may dis...

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Detaylı Bibliyografya
Asıl Yazarlar: Eftychia Vasili, Annekatrin König, Mohammed Al-Azzani, Clara Bosbach, Luisa Maria Gatzemeier, Searlait Thom, Ana Chegão, Hugo Vicente Miranda, Claudia Steinem, Daniel Erskine, Tiago F. Outeiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2025-10-01
Seri Bilgileri:npj Parkinson's Disease
Online Erişim:https://doi.org/10.1038/s41531-025-01159-w
Etiketler: Etiketle
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