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Transsynaptic complex dysfunction in the hippocampus of Alzheimer’s disease patients

IntroductionAlzheimer’s disease (AD) involves not only amyloid-β and tau pathology but synaptic dysfunction and impaired autophagy, though the underlying mechanisms and their relationship to AD progression are not well understood. Transsynaptic complexes involving presynaptic neurexins (Nrxn1/2/3),...

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Principais autores: Ashly Hindle, Yong Chen, Xiangling Yin, Maria Manczak, Boris Decourt, Volker Neugebauer
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-06-01
coleção:Frontiers in Aging Neuroscience
Assuntos:
Alzheimer’s disease
autophagy
hippocampus
human brain
neuroplasticity
transsynaptic signaling complex
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnagi.2026.1837327/full
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