mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion
We performed a systematic analysis of the translation rate of tumor-infiltrating lymphocytes (TILs) and the microenvironment inputs affecting it, both in humans and in mice. Measurement of puromycin incorporation, a proxy of protein synthesis, revealed an increase of translating CD4+ and CD8+ cells...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
eLife Sciences Publications Ltd
2021-11-01
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| Edice: | eLife |
| Témata: | |
| On-line přístup: | https://elifesciences.org/articles/69015 |
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